Continuous wave terahertz transmission imaging of nonmelanoma skin cancers.

BACKGROUND AND OBJECTIVE: Continuous wave terahertz imaging has the potential to offer a safe, noninvasive medical imaging modality for delineating human skin cancers. Terahertz pulse imaging (TPI) has already shown that there is contrast between basal cell carcinoma and normal skin. Continuous-wave imaging offers a simpler, lower cost alternative to TPI. The goal of this study was to investigate the feasibility of continuous wave terahertz imaging for delineating skin cancers by demonstrating contrast between cancerous and normal tissue in transmission mode. MATERIALS AND METHODS: Two CO(2) optically pumped far-infrared molecular gas lasers were used for illuminating the tissue at two frequencies, 1.39 and 1.63 THz. The transmitted signals were detected using a liquid Helium cooled Silicon bolometer. Fresh skin cancer specimens were obtained from Mohs surgeries. The samples were processed and imaged within 24 hours after surgery. During the imaging experiment the samples were kept in pH-balanced saline to prevent tissue dehydration. At both THz frequencies two-dimensional THz transmission images of nonmelanoma skin cancers were acquired with spatial resolution of 0.39 mm at 1.4 THz and 0.49 mm at 1.6 THz. For evaluation purposes, hematoxylin and eosin (H&E) histology was processed from the imaged tissue. RESULTS: A total of 10 specimens were imaged and it was determined that for both frequencies, the areas of decreased transmission in the THz image correlated well with cancerous areas in the histopathology. Two negative controls were also imaged. The difference in transmission between normal and cancerous tissue was found to be approximately 60% at both frequencies, which suggests that contrast between normal and cancerous tissue at these frequencies is dominated by differences in water content. CONCLUSIONS: Our results suggest that intraoperative delineation of nonmelanoma skin cancers using continuous-wave terahertz imaging is feasible.

Terahertz inverse synthetic aperture radar (ISAR) imaging with a quantum cascade laser transmitter.

A coherent transceiver using a THz quantum cascade (TQCL) laser as the transmitter and an optically pumped molecular laser as the local oscillator has been used, with a pair of Schottky diode mixers in the receiver and reference channels, to acquire high-resolution images of fully illuminated targets, including scale models and concealed objects. Phase stability of the received signal, sufficient to allow coherent image processing of the rotating target (in azimuth and elevation), was obtained by frequency-locking the TQCL to the free-running, highly stable optically pumped molecular laser. While the range to the target was limited by the available TQCL power (several hundred microwatts) and reasonably strong indoor atmospheric attenuation at 2.408 THz, the coherence length of the TQCL transmitter will allow coherent imaging over distances up to several hundred meters. Image data obtained with the system is presented.

Frequency stabilization of a single mode terahertz quantum cascade laser to the kilohertz level.

A simple analog locking circuit was shown to stabilize the beat signal between a 2.408 THz quantum cascade laser and a CH(2)DOH THz CO(2) optically pumped molecular laser to 3-4 kHz (FWHM). This is approximately a tenth of the observed long-term (t approximately sec) linewidth of the optically pumped laser showing that the feedback loop corrects for much of the mechanical and acoustic-induced frequency jitter of the gas laser. The achieved stability should be sufficient to enable the use of THz quantum cascade lasers as transmitters in short-range coherent transceivers.

Terahertz sideband-tuned quantum cascade laser radiation.

A compact, tunable, narrowband terahertz source was demonstrated by mixing a single longitudinal mode 2.408 THz, free running quantum cascade laser with a 2-20 GHz microwave sweeper in a conventional corner-cube-mounted Schottky diode. The sideband spectra were characterized with a Fourier transform spectrometer, and the radiation was tuned through several D(2)O rotational transitions to estimate the longer term (t > or = several sec) bandwidth of the source. A spectral resolution of 2 MHz in CW regime was observed.

Transformation of the multimode terahertz quantum cascade laser beam into a Gaussian, using a hollow dielectric waveguide.

We demonstrate that a short hollow dielectric tube can act as a dielectric waveguide and transform the multimode, highly diverging terahertz quantum cascade laser beam into the lowest order dielectric waveguide hybrid mode, EH(11), which then couples efficiently to the free-space Gaussian mode, TEM(00). This simple approach should enable terahertz quantum cascade lasers to be employed in applications where a spatially coherent beam is required.

The Energy Levels of the nu(5)/2nu(9) Dyad of HNO(3) from Millimeter and Submillimeter Rotational Spectroscopy.

In this paper we show that the rotational structure of the nu(5)/2nu(9) infrared band near 11 &mgr;m can be synthesized to high accuracy from pure rotational measurements in the millimeter- and submillimeter-wave region. The analysis uses an internal axis system Hamiltonian that accounts for the rotational dependence of the torsional splitting in 2nu(9), the induced torsional splitting in nu(5), and all of the infrared line positions, including those in the regions of strongest mixing and of highest excitation. This model also predicts the strength of the 2nu(9) infrared band due to the strong Fermi mixing with nu(5). The analysis is based on the 2317 millimeter/submillimeter lines and uses the well-documented SPFIT routines of JPL. Copyright 2001 Academic Press.